Editorial: Tumor-Derived Extracellular Vesicles: Protocols, Models, and Clinical Evidence

Editorial: Tumor-Derived Extracellular Vesicles: Protocols, Models, and Clinical Evidence

The current frontiers in Oncology are at the nanoscale (1). Within this nanoworld, new instruments and their related protocols enable the discovery or the improved characterization of bio-objects including extracellular vesicles (EVs). EVs, secreted by cells into the extracellular environment, include exosomes, microvesicles, and apoptotic bodies. Thus, EVs range from approximately 40 nm to a f...

Editorial: Novel Clinical Applications of Extracellular Vesicles

Cells employ several modes of communication, from direct contact to paracrine signaling. Understanding what they are whispering one to another has long been a goal for immunologists. In this scenario, the potential of a newly discovered way of sending specific messages between cell types, extracellular vesicles (EVs), has started a revolution in the field. During recent years, research on EVs h...

Extracellular Vesicles Derived from Gastrointestinal Microbiota: A New Approach to Clinical Studies

Extracellular vesicles, naturally released from all cell types including bacteria, are of great importance in medical microbiology due to transporting a variety of biomaterials, enzymes, and virulence factors, regulating immunity, and having roles in colonization and initiation of signaling pathways. These vesicles are also secreted from microbiota in the gastrointestinal tract and affect the h...

Immune Modulation by Tumor-Derived Extracellular Vesicles in Glioblastoma

Evidence-Based Clinical Use of Nanoscale Extracellular Vesicles in Nanomedicine.

Recent research has demonstrated that all body fluids assessed contain substantial amounts of vesicles that range in size from 30 to 1000 nm and that are surrounded by phospholipid membranes containing different membrane microdomains such as lipid rafts and caveolae. The most prominent representatives of these so-called extracellular vesicles (EVs) are nanosized exosomes (70-150 nm), which are ...